In general, these symptoms disappear during long-term treatment.
Hypotension (4%) with symptoms such as dizziness and nausea (1%) have been reported. They occur mainly in the early stages of treatment. Hypotension (4 to 5%), poor appetite (2.5%), nausea (1%) Īdverse effects associated with the clinical use of the drug are as expected with all nitrate preparations. Ĭommon: Tiredness, sleep disturbances (6%) and gastrointestinal disturbances (6%) have been reported during clinical trials with isosorbide mononitrate modified-release tablets, but at a frequency no greater than for placebo. Very common: Headache predominates (up to 30%) necessitating withdrawal of 2 to 3% of patients, but the incidence reduces rapidly as treatment continues. The following adverse effects have been reported in studies with isosorbide mononitrate: The oral, slow release tablet has an onset of thirty minutes, and a duration of 8 hours. The sublingual patch has an onset of five minutes and a duration of action of one hour. Isosorbide mononitrate is a nitrate-class drug used for the prevention of angina pectoris. In 2020, isosorbide was the 114th most commonly prescribed medication in the United States, with more than 5 million prescriptions. It was patented in 1971 and approved for medical use in 1981. It is believed to work by relaxing smooth muscle within blood vessels. Serious side effects may include low blood pressure especially if also exposed to PDE5 inhibitors such as sildenafil.
#Isosorbide mononitrate atc code skin#
Ĭommon side effects include headache, low blood pressure with standing, blurry vision, and skin flushing. It can be used both to treat and to prevent heart-related chest pain however, it is generally less preferred than beta blockers or calcium channel blockers. Isosorbide mononitrate, sold under many brand names, is a medication used for heart-related chest pain ( angina), heart failure and esophageal spasms.
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